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Central nervous system involvement in hairy cell leukemia (1985)

Knecht, H. ; Budmiger, H. ; Groscurth, P. ; [et al.]

Springer

Journal of molecular medicine 63 (1985), S. 423-427

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ISSN: 1432-1440

Keywords: Hairy cell leukemia ; Central nervous system involvement ; Methotrexate ; Interferon

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary A patient with central nervous system involvement by hairy cell leukemia is reported. Hairy cells were identified in the cerebrospinal fluid by electron microscopy and by tartrate-resistant acid phosphatase positive staining. Intrathecal treatment with methotrexate resulted in neurologic improvement, but was complicated by Cryptococcus neoformans meningitis. The leukemic phase of the disease was later successfully controlled by treatment with alpha interferon. Surface marker studies indicated a B- and T-cell phenotype of the hairy cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01733668

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