ISSN:
1432-1440
Keywords:
Alpha1 antitrypsin substitution
;
Protease inhibition
;
Mucosa inhibitors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The homozygote deficit of alpha1 antitrypsin (alpha1 PI-ZZ) in patients frequently results in a premature development of emphysema in the lung due to incomplete protection against proteases. An active inhibitor substitution appears to be useful. The presented study proves the biological effect of alpha1 antitrypsin infused into 8 patients. The results were an activity increase of leukocyte elastase and trypsin inhibition in serum as well as doubling of alpha1 antitrypsin in sputum. This therapeutical conception (with a dose of 60 mg/kg body weight/week) results in an efficient protection. Inhibitors specific for mucosa are not influenced. An improvement of lung function during 6 weeks of intravenous therapy was not achieved. The progressive destruction of lung parenchyma can be probably prevented, however.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01741387
