ISSN:
1432-0428
Keywords:
Growth hormone
;
hypophysectomy
;
plasma growth hormone
;
plasma insulin, insulin release
;
perifusion
;
cultured rat islets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Growth hormone injected intravenously in the rat elicited a 6-fold spike change in immunoreactive insulin with little variation in glucose. Subcutaneous administration of growth hormone for 4 days augmented by 56% the insulin-secretory response to glucose of isolated islets from hypophysectomised rats but not the response of control rat islets. When islets were cultured in the presence of growth hormone, the glucose-induced insulin release was increased by 35% in batch incubations of islets from both normal and hypophysectomised rats and by 70–110% in perifused islets. Thus the capacity for stimulated release of insulin is limited by hypophysectomy, and growth hormone is capable of directly influencing the secretory function of the β- cell.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280526
