ISSN:
1432-0428
Keywords:
Type 1 diabetes
;
children
;
insulin antibodies
;
C-peptide
;
partial remission
;
insulin requirement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Insulin antibodies expressed as insulin binding capacity of IgG were determined in 50 Type 1 (insulin-dependent) diabetic children who have been treated with monocomponent porcine insulin from the onset of the disease. During the follow-up period of 0.5–5.5 years (mean±SD: 3.2±1.6 years), 26 out of 50 patients (52%) developed detectable insulin antibodies. These patients had significantly lower maximal C-peptide responses to a standardized breakfast 9 months after onset of diabetes (mean 0.24pmol/m1, p〈0.001) than those without insulin antibodies (mean 0.47 pmol/ml). In addition, patients with antibodies showed both significantly higher insulin requirements at 9 months (p〈0.05), and shorter remissions (p〈0.01) than those without. It is concluded that even ‘small’ amounts of insulin antibodies may be biologically significant and have negative effects on B-cell function and metabolic balance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00281121
