ISSN:
1432-0428
Keywords:
Type 1 diabetic patients
;
exercise
;
plasma prostanoids
;
6-keto-PGF1α
;
TXB2 and PGE2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The capacity of prostacyclin production determined as plasma 6-keto-PGF1α was investigated in 12 Type 1 (insulin-dependent) diabetic patients with a median duration of diabetes of 14 years during ordinary metabolic control. Using high pressure liquid chromatography preceding radioimmunoassay, the plasma concentration of 6-keto-PGF1α, the stable metabolite of prostacyclin, was determined at rest and after a standardised bicycle exercise test. The plasma 6-keto-PGF1α in diabetic patients at rest did not differ from that of 25 healthy volunteers; 2.9 pg/ml (range〈0.2–15.3) versus 1.7 pg/ml (range〈0.2–16.6). During the exercise test plasma 6-keto-PGF1α increased significantly in the diabetic patients as well as in the control group (p〈 0.05). The increment of 6-keto-PGF1α in the diabetic patients was neither related to the metabolic regulation, duration of diabetes nor to changes in platelet volume, platelet number or the production of thromboxane B2 and prostaglandin E2. Our results do not support the hypothesis that Type 1 diabetic patients have a decreased capacity of prostanoid production, as suggested from in vitro studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00279612
