ISSN:
1432-2277
Keywords:
Pancreas transplantation, microangiopathy
;
Microangiopathy, pancreas transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Using videophotometric capillaroscopy and laser Doppler fluxmetry, we have investigated skin microvascular reactivity in the fingers of 14 diabetic patients with severe, late complications 20 months after combined kidney and pancreas transplantation. The results were compared with those obtained in 20 diabetic patients awaiting pancreas transplantation and in 19 healthy subjects. The capillary blood cell velocity at rest (P〈0.01) and during postocclusive reactive hyperemia (P〈0.05) was significantly lower in both patient groups than in the healthy controls. However, the time to peak capillary blood cell velocity during hyperemia was normal in the post-transplantation group (NS) but significantly prolonged in the pretransplantation group (P〈0.01). The ability to decrease flow during venous stasis—the so called venoarte-riolar reflex—was strongly impaired in the pretransplantation group (P〈0.001) but less so in the post-transplantation group (P〈0.05) as compared to healthy controls. It may be concluded that diabetic patients, after combined kidney and pancreas transplantation, show a tendency towards better microvascular reactivity than those awaiting transplantation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00355465
