ISSN:
1432-072X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The effect of inhibitors of carotenoid synthesis, diphenylamine, acridine, and acriflavin on catalase induction was studied in Rhodopseudomonas spheroides. The induction of catalase by 40 μM H2O2, was inhibited 5x10-4 M acridine, 5 μM acriflavin and 3x10-4 diphenylamine. Acridine, acriflavin and diphenylamine at 1.0x10-4 M, 1.5 μM and 5x10-5 M respectively, stimulated the induction. The stimulatory effect was shown to be at the transcriptional level rather than at the translational level. The concentration of acridine which stimulated the induction of the enzyme inhibited general protein synthesis in the cell, under similar conditions. Acriflavin also did not stimulate the induction of β-galactosidase in Escherichia coli B. It is suggested that these acridine dyes interact with the internal inducer-DNA complex which leads to a higher rate of production of catalase mRNA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00408973
