ISSN:
1432-0738
Keywords:
Soman intoxication
;
Acute phase reactants
;
Corticosterone
;
Immunosuppressive potency of serum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We have studied the effect of soman intoxication on serum acute phase reactants (APR) levels, and the relationship of the APR and corticosterone concentrations and the immunosuppressive activity of the serum. One day after the injection of 1.8 LD50 soman the concentrations of α2-macroglobulin (α2-MG) and α1-acid glycoprotein (AGP) in the serum of antidote protected rats increased 4- and 7-fold, respectively, whereas those of hemopexin (Hx), haptoglobin (Hp) and cysteine protease inhibitor (CPI) were two to three times higher than in the controls. A similar magnitude of increase of serum acute phase reactants levels was observed when 0.3 LD50 soman was administered at 24-h intervals over the 5-day period. The relationship of changes in the APR concentration, corticosterone level and immunosuppressive activity of the serum was also comparable to that observed in the acute phase response to tissue injury.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00303131
