ISSN:
1432-1912
Keywords:
Tritium Labelled Hexamethonium
;
Whole Body Autoradiography
;
Distribution
;
Accumulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Distribution and accumulation of intravenously and subcutaneously injected tritium-labelled hexamethonium has been studied in mice using autoradiography of whole body sections. The bis-quaternary ammonium compound is rapidly distributed over the organism and excreted mainly by the kidneys, less with the bile. Due to its affinity to “negative binding sites” it combines with acid mucopolysaccharides and is accumulated therefore considerably in connective and cartilaginous tissues. 30 min after either injection route the general distribution pattern of hexamethonium in the organism is characterized as follows (decreasing order): Kidneys, urinary tract, cartilage and connective tissue ≫ lungs 〉 blood, liver 〉 heart and skeletal muscle, gastric and intestinal wall 〉 spleen 〉 adipose tissue, brain and spinal cord.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01002352
