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Effects of the renin inhibitor pepstatin on the blood pressure on intact and nephrectomized rats (1972)

Lazar, J. ; Orth, H. ; Möhring, J. ; [et al.]

Springer

Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 114-118

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ISSN: 1432-1912

Keywords: Pepstatin ; Renin-Angiotensin System ; Nephrectomy ; Proteinase Inhibitor

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Pepstatin, an N-acylated pentapeptide isolated from culture filtrates of streptomycetes, has been shown in previous experiments to inhibit the reninsubstrate reaction in vitro. On the basis of blood-pressure measurements in the rat it is suggested that pepstatin affects the reaction of both endogenous and exogenous heterologous renin with plasma substrate. Besides this effect, pepstatin has a slight non-specific hypotensive action, as demonstrated in the nephrectomized rat.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00505072

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