Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
279 (1973), S. 9-18
ISSN:
1432-1912
Keywords:
Aldosterone Antagonists
;
β-Methyl-Digoxin
;
Guinea Pigs
;
Potassium
;
Cardiac Toxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of aldosterone antagonists on the cardiotoxicity of β-methyl-digoxin in guinea pigs were investigated in vivo and in vitro. 1. Three days of pretreatment with spironolactone influenced neither plasma concentrations, urinary output and tissue distribution of radioactivity after intravenous injection of β-methyl-digoxin nor the pattern of lipid soluble metabolites in the urine. 2. Spironolactone injected intraduodenally 1 h before the infusion of β-methyl-digoxin decreased the cardiotoxicity of the latter if hypokalemia was reduced or prevented by giving 0.4–1.0 mEq/kg KCl 1 h before β-methyl-digoxin. 3. Three days of pretreatment with canrenoate-K decreased the cardiotoxicity of β-methyl-digoxin in vivo without the administration of KCl. 4. Isolated hearts from guinea pigs pretreated with canrenoate-K for 3 days tolerated the perfusion with toxic concentrations of β-methyl-digoxin better than those from controls although the rate of potassium extrusion from the heart was not decreased. 5. The addition of canrenone to the fluid perfusing isolated hearts decreased the potassium extrusion produced by and the toxicity of β-methyl-digoxin. The results suggest that the decreased glycoside toxicity is due to the stimulation of inward transport of potassium by aldosterone-antagonists described in the preceding paper.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00502063
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