ISSN:
1432-1912
Keywords:
Anaphylaxis
;
Catecholamines
;
Prostaglandins
;
Slow-Reacting Substance
;
Histamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In sensitized perfused guinea pig lungs antigen (ovalbumin) released prostaglandins (Pgs) F2α and E2, slow-reacting substance of anaphylaxis (SRS-A), and histamine. Furthermore, high amounts of the metabolite 15-keto-13,14-dihydro-PgF2α were found. Accordingly, perfusion of nonsensitized lungs with PgF2α and E2 resulted in extensive destruction of both substances. Simultaneously with the mediator release, very intense bronchospasm and pulmonary vascular constriction occurred. Administration of histamine in nonsensitized lungs resulted in Pg release. Isoproterenol as well as adrenaline prevented the anaphylactic mediator release, and concemitantly inhibited the spastic effects in the lungs. Propranolol reversed these actions of the catecholamines. Also indomethacin abolished the prostaglandin release, but increased the liberation of SRS-A. The findings are discussed in view of the contraregulatory function of adrenaline in anaphylaxis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500347
