ISSN:
1432-1912
Keywords:
cAMP/cGMP ratio
;
Tyrosine hydroxylase induction
;
Reserpine
;
Dexamethasone
;
Hypophysectomy
;
Adrenal medulla
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pretreatment of rats with dexamethasone (2.5 μmol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine-mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisites for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00498878
