ISSN:
1432-1912
Keywords:
Adenosine
;
Adenosine analogs
;
Phosphodiesterase activity
;
Heart
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Adenosine and its analogs (-)-N6-phenylisopropyladenosine and 5′-N-ethylcarboxamideadenosine inhibit cAMP and cGMP phosphodiesterase activity in guinea-pig atrial and ventricular preparations at concentrations of 100 μmol l−1 and higher. These effects are probably unrelated to the inotropic effects of these substances. However, inhibition of cAMP breakdown may compensate for the adenosine-induced inhibition of adenylate cyclase and may thus at least partially explain why with this drug no changes in cAMP or cGMP content have previously been observed in intact cardiac tissue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00512074
