ISSN:
1432-1912
Keywords:
Phencyclidine
;
Methamphetamine
;
Hyperthermia
;
Brain histamine
;
α-Fluoromethylhistidine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We compared the effects of phencyclidine (PCP) and methamphetamine on body temperature and brain histamine turnover in mice. Methamphetamine at 5 and 10 mg/kg produced dose-related increases in rectal temperature, whereas PCP given in the same doses had no significant effect. In mice pretreated with α-fluoromethylhistidine, an inhibitor of histidine decarboxylase, PCP produced a marked hyperthermia. PCP markedly accelerated brain histamine turnover, as measured by the accumulation of telemethylhistamine, a predominant metabolite of brain histamine, following administration of pargyline. Methamphetamine had no significant effect on the histamine dynamics. These results suggest involvement of brain histaminergic neurons in the action of PCP but not methamphetamine, and the presence of a histaminergic thermoregulatory mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00504870
