ISSN:
1432-1912
Keywords:
Adrenal medulla
;
Catecholamine secretion
;
Nicotinic receptor-ion channel complex
;
Sodium influx
;
Vecuronium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In cultured bovine adrenal medullary cells, vecuronium, pancuronium and D-tubocurarine reduced carbachol-induced45Ca2+ influx and catecholamine secretion by inhibiting22Na+ influx via nicotinic receptor-ion channel complex with IC50 values of 0.43, 7.6 and 3.9μmol/l, respectively. IC50 values of pancuronium and D-tubocurarine observed in adrenal medulla were one order of magnitude higher than the plasma concentrations of these muscle relaxants reported to produce 50% neuromuscular blockade, while IC50 of vecuronium was quite close between adrenal medulla and skeletal muscle.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00717734