ISSN:
1432-1912
Keywords:
Chronic haloperidol
;
Dopamine D2 receptors
;
NMDA receptors
;
AMPA receptors
;
Caudate-putamen
;
Quantitative autoradiography
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The aim of the present study was to investigate the influence of chronic treatment with haloperidol on the striatal N-methyl-D-aspartate (NMDA), α-amino-3-hydro-xy-5-methyl-4-isoxasole-propionic acid (AMPA) and dopamine D2 receptors using a quantitative autoradiography in rats. Haloperidol was given to animals in a dose of ca. 1 mg/kg/day in drinking water for 6 weeks or 3 months and was afterwards withdrawn for 5 days. Haloperidol increased by 20–50% the binding of [3H]spiperone in different regions of the caudate-putamen. Haloperidol decreased by ca. 30% the binding of [3H]AMPA in the ventrolateral region of intermediate part of the caudate-putamen, but did not influence the binding of [3H]MK-801. The present results suggest that, apart from supersensitivity to dopamine, chronic treatment with haloperidol also induces subsensitivity of striatal AMPA receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171073
