ISSN:
1432-2072
Keywords:
Nootropics
;
Cholinomimetics
;
Corticosteroids
;
Memory improvement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Oral pretreatment of mice with aldosterone or corticosterone blocked the memory-enhancing effects of piracetam, pramiracetam, aniracetam and oxiracetam in a dose-related manner, without, however, impairing the animals' learning performance. The improvement of memory induced by physostigmine, arecoline, and tacrine (THA) was similarly inhibited. The fact that elevated steroid levels suppress the memory-enhancing effects of entirely different substances could indicate that these substances have a common site of action. In the light of new observations showing increased cortisol concentrations in Alzheimer patients, this steroid dependency of the effects of memory enhancers might explain why only a limited number of these patients respond to therapy with nootropics or cholinomimetics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02245278
