ISSN:
1432-2072
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Concurrent observations were made on the rope-climbing performance and aromatic excretion pattern of male albino rats during drug treatment. Iproniazid, Niamid and Isoniazid were administered chronically and Reserpine was given in single doses, alone, and in combination with the Iproniazid. 1. Iproniazid and Niamid disturbed the climbing habit which later became re-established even though drug treatment was continued. Urinary concentrations of 5-hydroxyindoleacetic acid fell and of tryptamine rose immediately on giving the drugs, and tryptophane excretion gradually increased. 2. Isoniazid had little effect on climbing performance. 3. A study of T.M. 6 was abandoned when large sores developed at the site of injection. 4. Reserpine given alone disrupted climbing and potentiated excretion of 5-hydroxyindoleacetic acid, tryptophane and two unidentified Ehrlich positive materials. 5. When given on the second day of Iproniazid treatment, Reserpine also disrupted climbing and increased excretion of 5-hydroxyindoleacetic acid, tryptamine and tryptophane. When given on the 23rd day, the climbing performance was impaired but no change was observed in excretion pattern. 6. Some physiological and overall behaviour changes during the experiments are described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00411196
