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Enhancement of methylphenidate-induced stereotypies by repeated administration of neuroleptics (1974)

Fjalland, B. ; MØller Nielsen, I.

Springer

Psychopharmacology 34 (1974), S. 105-109

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ISSN: 1432-2072

Keywords: Methylphenidate ; Gnaw Compulsion ; Tolerance ; Dopamine Turnover ; Receptor Sensitivity

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The intensity of methylphenidate-induced gnaw compulsion was investigated in haloperidol-tolerant mice and in normal mice. In the withdrawal phase after repeated administration of haloperidol (1.25 mg/kg p.o./day, 5 days), methylphenidate caused a significant increase in stereotyped gnawing as compared to the effect in normal mice. It is proposed that the mechanism behind this increase in response to methylphenidate could be increased receptor sensitivity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00421934

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