ISSN:
1432-2072
Keywords:
Phenylethylamine
;
Phenylethanolamine
;
Neuromodulators
;
Evoked Responses
;
Electroshock
;
Mouse Behavior
;
Rabbit
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The electrophysiological and behavioral effects of phenylethanolamine (OHPEA) and of its precursor 2-phenylethylamine (PEA) were studied in mice and rabbits. In animals pretreated with MAOI, PEA was found to exert strong amphetamine-like effects, EEG alerting, reduction of visual evoked responses, increased locomotor activity, and blockade of tonic seizures induced by electroshock. OHPEA exerted weaker amphetamine-like effects. Inhibition of dopamine-Β-hydroxylase increased most of the effects of PEA. In non-pretreated animals, OHPEA was found to shorten electroshock latency and to prolong the duration of visual evoked responses. PEA (but not OHPEA) potentiated the excitement induced by δ9-tetrahydrocannabinol in MAOI-pretreated mice. Reserpine pretreatment reduced but did not abolish the CNS effects of OHPEA and PEA. One may speculate that endogenous PEA is more likely to serve as a modulator for ergotropic functions than is endogenous OHPEA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429541
