ISSN:
1432-2072
Keywords:
Anxiety
;
Punishment
;
Conflict
;
Chlordiazepoxide
;
β-Carboline carboxylic acid ethyl ester
;
Ro 15-1788
;
ACTH(4–10)
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The antagonism of the anticonflict effect of chlordiazepoxide (CDP) by β-carboline carboxylic acid ethyl ester (BCCE), Ro 15-1788 and ACTH(4–10) has been evaluated in the Geller-Seifter rat conflict test in which CDP increases punished (conflict), but not unpunished responding. BCCE (0.5–10 μg ICV) produced a dose-dependent reduction in the anticonflict activity of CDP. This was also significantly reduced by Ro 15-1788 (25 mg/kg IP) and a high dose of ACTH(4–10) (5 μg ICV). None of these test compounds had a marked direct effect on punished or unpunished responding in the doses used. These experiments provide further physiological support for the suggestion from binding studies that BCCE and Ro 15-1788 act on benzodiazepine receptors. However, the ability of ACTH(4–10) to reduce the anticonflict effect of CDP may be by some other, possibly opioid, mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428161
