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Effects of carbamazepine on cerebrospinal fluid somatostatin (1985)

Rubinow, David R. ; Post, Robert M. ; Gold, Philip W. ; [et al.]

Springer

Psychopharmacology 85 (1985), S. 210-213

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ISSN: 1432-2072

Keywords: Carbamazepine ; Somatostatin ; Cerebrospinal fluid ; Affective illness

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticovulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to increase CSF somatostatin in a small number of patients. The potential mechanism and significance of the effects of carbamazepine on CSF somatostatin are discussed in relation to the psychotropic, anticonvulsant, and analgesic properties of carbamazepine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00428416

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