ISSN:
1432-2072
Keywords:
Electroconvulsive shock
;
5-HT transporter complex
;
β-Adrenoceptor
;
[3H]-Paroxetine
;
[3H]-Imipramine
;
[3H]-Dihydroalprenolol
;
Cerebral cortex
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of repeated electroconvulsive shock on the 5-HT uptake site were studied in rat cortex using [3H]-paroxetine binding. This ligand was used because it is thought to directly label the 5-HT uptake site, whereas [3H]-imipramine may bind to a presynaptic recognition site different from the uptake site. No changes were found in the maximum number of [3H]-paroxetine binding sites and equilibrium dissociation constant after repeated electroconvulsive shock, whereas a parallel investigation of β-adrenoceptor binding showed the expected decrease in receptor number.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00212769
