ISSN:
1432-2013
Keywords:
Water Electrolyte Balance
;
Sodium
;
Thirst
;
Renal Artery Obstruction
;
Renal Hypertension
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Rats with spontaneous hypertension and rats with experimental hypertension elicited by constriction of one renal artery exhibited an enhanced sodium appetite similar to patients with essential hypertension. The hypertensive rats drank twice as much saline (0.9 g NaCl/100ml) as the controls, when given the choice between tap water and saline. In the rats with unilaterally constricted renal artery water intake was increased and plasma sodium concentration reduced. In these animals, body weight increased by 1.6%, plasma sodium returned to normal and polydipsia disappeared after the intake of saline. Polydipsia, hyponatremia and enhanced sodium appetite likewise disappeared after the removal of the contralateral kidney exposed to the high blood pressure. It is concluded from these results, that the natriuresis of the kidney exposed to the elevated blood pressure causes the enhanced sodium appetite and the polydipsia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00603814
