ISSN:
1432-2013
Keywords:
Whole-cell current
;
Ca2+-dependent K+ channels
;
Tetraethylammonium
;
Salivary secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Using whole-cell patch-clamp techniques, we demonstrate, for the first time, that rat submandibular acinar cells contain a tetraethylammonium (TEA)-insensitive, Ca2+-activated K+ conductance which is not attributable to large conductance, voltage-sensitive, Ca2+-dependent K+ channels (maxi-K+ channels). Taken together with our recent K+ efflux and fluid secretion studies in intact rat submandibular gland, we postulate that the K+ conductance reported here may be involved in the basolateral K+ efflux pathway activated by cytosolic Ca2+ concentration during secretion by this gland.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00373998
