ISSN:
1432-0797
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract A new simple strategy for a reliable and robust automatic control of the specific growth rate in fed-batch cultivation processes is presented. Its advantages over model supported control is that the algorithm only needs a minimum of information about the process. Moreover, it is independent of the specific microorganism, the cultivation phase and the biomass level. Also, only a minimum of soft- and hardware is required. Hence, the approach is attractive for industrial production processes that do not have specialized instrumentation. Its accuracy is comparable with model supported control and thus sufficient for most industrial applications. Simulations and experimental tests of the technique performed for the example of a fed-batch cultivation of E. coli demonstrate a good controller performance for various cultivation conditions and process disturbances. Preferred applications will be production systems where the productivity is critically dependent on the growth rate, e.g. in recombinant protein or antibiotic productions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00369618
