ISSN:
1432-1106
Keywords:
Brain cortex slices
;
Membrane transport of macromolecules
;
Inulin space
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Light and electron microscope autoradiography indicated that 3H-labelled inulin was taken up by neurons and glia cells of rat brain cortex in vitro. The mechanism, by which inulin passed the cell membranes, was studied by comparing the transport of inulin (molecular weight 5000) with the transport of dextran (molecular weight 75000). The half-time for the cellular in- and efflux for the two molecules was the same although their diffusion coefficients differed by a factor of 4–5. The transport mechanism was therefore interpreted as bulk transport, and vesicular transport is suggested. Efflux of inulin from brain cortex exposed to inulin in vivo indicated that cellular uptake of inulin also occured in vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00237084
