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Differential effects of enkephalin within hippocampal areas (1981)

Tielen, A. M. ; Lopes da Silva, F. H. ; Mollevanger, W. J. ; [et al.]

Springer

Experimental brain research 44 (1981), S. 343-346

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ISSN: 1432-1106

Keywords: Hippocampus ; Dentate gyrus ; Enkephalins ; Neuropeptides

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The synthetic opiate D-Alaninemethionine enkephalin (D-Ala) affects neuronal activity of the fascia dentata (FD). D-Ala causes a depression of the population spike evoked by stimulation of the perforant path, which is antagonized by naloxone. In so called “Tandem” experiments it was shown that D-Ala had opposite effects on the CA1 pyramidal and FD granule cells. It is likely that in the FD the site of action of D-Ala is at the afferent synapses.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00236574

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