ISSN:
1432-1041
Keywords:
digitoxin
;
digoxin
;
3H-digitoxin
;
3H-digoxin
;
pharmacokinetics
;
individualization of maintenance dose
;
urine metabolites
;
long-term treatment
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Patients suffering from congestive heart failure received maintenance doses of digitoxin (N=10) or digoxin (N=8). The plasma glycoside concentration was determined, and after a single dose of3H-digitoxin or3H-digoxin, the decline and excretion of radioactivity were measured over a period of 7 (digitoxin) and 3 days (digoxin). Plasma radioactivity declined with a x T1/2β between 77 and 234 h (mean 138 h) in the case of digitoxin and with a x T1/2β between 9.2 and 38.6 h (mean 23.5 h) for digoxin. A close correlation between x T1/2β and excreted radioactivity and x T1/2β and total plasma level was found for digitoxin. In 4 patients TLC of urine showed that interindividual variations in digitoxin elimination could possibly be attributed to variation in metabolism, resulting in the production of different metabolites. Predicted digitoxin plasma levels agreed well with measured values. The maintenance dose could be calculated from the total body clearance (κVCl) and a presumed plasma glycoside level. The recommended technique facilitates dosage calculations in patients treated with digitoxin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558383
