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Pharmacokinetics of digoxin in pregnancy (1983)

Luxford, A. M. E. ; Kellaway, G. S. M.

Springer

European journal of clinical pharmacology 25 (1983), S. 117-121

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ISSN: 1432-1041

Keywords: serum digoxin ; pregnancy ; digoxin-renal-clearance ; creatinine-clearance ; digoxin-elimination ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Digoxin-renal-clearance, creatinine-clearance, 24-h urine elimination of digoxin and serum digoxin were studied in 15 patients in the third trimester of pregnancy and 6 to 12 weeks post-partum. There was significant fall post-partum in the first three. There was also a significant fall post-partum in serum digoxin levels. This finding was unexpected, but may be due to heightened absorption exceeding increased elimination because of the physiological status in pregnancy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544027

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