ISSN:
1432-1041
Keywords:
digoxin
;
concentration plateau
;
pharmacokinetics
;
systolic time intervals
;
optimal infusion scheme
;
dose-response data
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Using a volume-controlled infusion pump, a mean serum plateau level of digoxin of 4–5 ng/ml was rapidly achieved and maintained in 6 healthy volunteers. The infusion scheme was calculated on the basis of data published on the pharmacokinetics and pharmacodynamics of digoxin following bolus intravenous injection. The magnitude of the response (change in electromechanical systole) at the end of the plateau phase was comparable to that observed with the concentration in the therapeutic range at steady state.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542110
