ISSN:
1432-1041
Keywords:
phenprocoumon
;
oral anticoagulant
;
metabolites in plasma
;
patients
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Pooled plasma from patients receiving phenprocoumon anticoagulant therapy was extracted and the following substances were characterized: phenprocoumon, and its 7-hydroxy,4′-hydroxy and 6-hydroxy derivatives; they were identified by HPLC and after methylation by quartz capillary GC-MS using the electron impact and selective ion monitoring modes. This is the first occasion when phenprocoumon metabolites have been identified in plasma; they were unconjugated and in much lower concentrations (43.2 and 2 ng/ml for the 7,4′ and 6-hydroxy derivatives, respectively) than the original compound (2000 ng/ml).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00635898
