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Pharmacokinetic parameters of bevantolol in volunteers (1986)

Vermeij, P. ; Brummelen, P.

Springer

European journal of clinical pharmacology 30 (1986), S. 375-377

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ISSN: 1432-1041

Keywords: bevantolol ; pharmacokinetics ; beta-blocking drugs

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetics of the new beta-adrenoceptor blocking drug bevantolol and some aspects of its beta-blocking effect have been studied in healthy volunteers. Bevantolol had a short serum half-life (86±33 min) and high systemic availability after oral administration. The observed changes in heart rate, systolic blood pressure during excercise and plasma renin activity were all compatible with beta-adrenoceptor blockade. After 200 mg p.o. in the morning, the effects lasted for less than 24 h.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00541549

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