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Digitale Medien

Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid (1987)

Miskolczi, P. ; Vereczkey, L. ; Szalay, L. ; [weitere]

Springer

European journal of clinical pharmacology 33 (1987), S. 185-189

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Details

ISSN: 1432-1041

Schlagwort(e): vinpocetine ; apovincaminic acid ; healthy volunteers ; elderly subjects ; pharmacokinetics ; age effect

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA), were studied in the aged. Vinpocetine was eliminated with a mean half-life of 2.12±0.51 h. Total plasma clearance (CL) and distribution coefficient (Δ) of the parent drug were 2.2±0.9 l · kg−1 · h−1 and 6.7±3.7 l · kg−1, respectively. The CL and Δ of vinpocetine differed significantly from young subjects but the elimination half-life was not altered. Significant changes in the elimination half-life and plasma clearance of AVA were found, perhaps because of the physiological decrease in renal function.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00544565

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