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  • 1
    Electronic Resource
    Electronic Resource
    Smoking and body weight influence the clearance of chlorpromazine (1994)
    Springer
    European journal of clinical pharmacology 46 (1994), S. 523-526 
    Details
    ISSN: 1432-1041
    Keywords: Chlorpromazine ; Schizophrenic patients ; population pharmacokinetics ; clearance ; cigarette smoking ; cannabis smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The population pharmacokinetic parameters of chlorpromazine (CPZ) in chronic schizophrenic patients were evaluated using 189 plasma concentration measurements from 31 patients. A NONMEM analysis demonstrated that the clearance of CPZ depended on the patient's body weight. Cigarette smoking and cannabis smoking increased the clearance of CPZ. Chronic alcohol consumption and the concurrent use of anticholinergics did not appear to influence the clearance of CPZ significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00196109
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