ISSN:
1432-1041
Keywords:
Warfarin
;
ethyl biscoumacetate
;
acenocoumarin
;
phenindione
;
fluoropindione
;
albumin binding
;
phenylbutazone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Ethyl biscoumacetate and acenocoumarin are bound to the same sites on human albumin as warfarin. Phenindione and fluorophenindione are bound to other sites. Phenylbutazone inhibits binding of the former but has no effect on the latter. These results can account for the fact that clinical reports of interaction between phenylbutazone and vitamin K antagonists involve only coumarin drugs, especially warfarin, and not phenindione derivates.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00561795