ISSN:
1432-1041
Keywords:
Procaine amide
;
N-acetylprocaine amide
;
plasma concentration
;
renal excretion
;
acetylator phenotype
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The metabolism of procaine amide was studied in 41 cardiac patients who had achieved steady state plasma concentrations of the drug. Acetylated procaine amide accounted for 31±12% (range 16 – 63%) of the overall urinary recovery of the drug and is therefore a main metabolite in man. Plasma levels of the metabolite were usually lower but sometimes exceeded those of the parent compound with variations between 1 and 15 µg/ml. The metabolite had a weaker effect than procaine amide on the maximal electrical driving velocity of isolated atrial strips from guinea pig.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00616419
