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Urothelial carcinogenesis and portocaval anastomosis in the rat (1987)

Wallace, D. M. A. ; Ackermann, D. ; Davis, B. ; [et al.]

Springer

Urological research 15 (1987), S. 195-197

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ISSN: 1434-0879

Keywords: Portacaval anastomosis ; Urothelial carcinogenesis ; Uric acid calculi ; Dietary tryptophan

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Portacaval anastomoses were performed in the rat to study urothelial carcinogenesis in this model and the promoting effect of dietary tryptophan. We were unable to produce any urothelial cancers or premalignant changes; some animals formed uric acid stones and developed papillary hyperplasia in the bladder. We conclude that the initiating carcinogen is likely to be exogenous and may be dietary in those experiments that have produced urothelial cancers.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00262098

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