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Digitale Medien

Functional characterization of the H-2Dp gene product (1984)

McLaughlin-Taylor, Elizabeth ; Woodward, Jerold G. ; Macchi, Mary J. ; [weitere]

Springer

Immunogenetics 19 (1984), S. 205-216

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Details

ISSN: 1432-1211

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract A λ clone containing the D p gene was used to transform L cells. The Dp product expressed was identified by two-dimensional gel electrophoreis and flow cytometry. The Dp product expressed by the L cells was recognized by DP-specific flow cytometry. The Dp product expressed by the L cells was recognized by Dp-specific but not Kp-specific killer T cells. This killing was inhibited by monoclonal antibodies specific for Dp but not Kp or Kk antigens. Similarly, lymphocytic choriomeningitis virus (LCMV) killer T cells from B 10.P mice were able to kill LCMV-infected L12a cells, but not LCMV-infected Ltk+. Again only Dp monoclonal antibodies could inhibit this killing.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00364764

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