ISSN:
1619-7089
Keywords:
[11C]Dimethyltryptamine
;
Serotonin receptors
;
Positron
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were greatly enhanced by pretreatment with the monoamine oxidase inhibitor, pargyline. Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00276707
