Electronic Resource
Springer
European journal of nuclear medicine
6 (1981), S. 245-248
ISSN:
1619-7089
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Methyl N-carbobenzoxy-β-iodo-D-alaninate (1) served as an intermediate to synthesize methyl β-iodo-D-alaninate (2) and β-iodo-D-alanine (3). The 125I-labeled compound 1 was synthesized by the melt method and used to synthesize 125I-labeled compounds 2 and 3. Compound 3 was shown to be substrate for D-amino acid oxidase. It was also shown that compounds 2 and 3 were rapidly eliminated from normal mammalian tissues and that compound 3 inhibited the Escherichia coli growth in a dose-dependent manner at 100–500 μg/ml while compound 2 showed no effect at 500 μg/ml level. Therefore, it was suggested that compound 3 may serve as an abscess localizing agent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00251346
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