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Acute mucocutaneous toxicity following high-dose hydroxyurea (1993)

Brincker, Hans ; Christensen, Bjarne Egelund

Springer

Cancer chemotherapy and pharmacology 32 (1993), S. 496-497

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ISSN: 1432-0843

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Three patients with advanced acute myeloid leukemia were treated with oral high-dose hydroxyurea at a dose of 10 g daily for 8–10 days. Severe acute stomatitis developed in all three patients. In addition, two of the patients developed a peculiar acute cutaneous type of toxicity associated with soreness, violet erythema, and edema of the palms and foot soles followed by intense universal hyperpigmentation of the skin. Apparently, the pronounced acute mucocutaneous toxicity was caused by the sustained high daily dose of hydroxyurea, indicating that myelosuppression may not be the dose-limiting toxicity of this drug.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00685897

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