ISSN:
1432-0843
Keywords:
Key words Etoposide
;
Circadian variation
;
Low-dose infusion
;
Lung cancer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The prolonged continuous infusion of low-dose etoposide is a new approach to treating cancer. Whether or not a circadian variation in the plasma levels of etoposide existed was investigated in nine patients with non-small-cell lung cancer. Etoposide was infused for 14 days and blood samples were obtained every 4 h for 1 day. There was no significant circadian variation, and the observed small within-day variations seemed to lack clinical significance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002800050438