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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 16 (1970), S. 154-160 
    ISSN: 1432-0533
    Keywords: Hyperactivity ; Succinoxidase Activity ; Reticular Neurons ; β-β-Iminodipropionitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Succinooxidaseaktivität einzelner Neurone aus der Formatio reticularis wurde mit der Cartesianischen Tauchertechnik gemessen. Die Durchschnittsaktivität der Nervenzellkörper des Nucleus gigantocellularis sowie des Nucleus pontis caudalis der Kontrollratten war 4,5 μl O2×10−4 pro Stunde bei 37°C. Nachdem die Ratten β-β-Iminodipropionitril bekommen hatten, stieg die Durchschnittsaktivität derselben Neurone bis auf 8.0 μl O2·10−4 an. Es wird angenommen, daß dieser Anstieg für die sich später entwickelnden Hyperaktivitätssymptome ätiologische Bedeutung besitzt. Auch wenn β-β-Iminodipropionitril zu reticulären Neuronen normaler Ratten in vitro gegeben wurde, stieg die Succinooxidaseaktivität bis auf 8,4 μl O2·10−4 pro Stunde an.
    Notes: Summary The succinoxidase activity of single neurons from the reticular formation was measured with the Cartesian diver technique. The average activity of nerve cell bodies from the nucleus gigantocellularis or pontis caudalis from control rats was 4.5 μl O2×10−4 per hour at 37°C. After rats had received β-β-iminodipropionitrile, the succinoxidase activity of the same type neuron increased to an average of 8.0 μl O2×10−4. It was suggested that this increase was of etiological significance for the symptoms of hyperactivity which developed later. Also when β-β-iminodipropionitrile had been added to the reticular neurons from normal rats in vitro, the succinoxidase activity increased to 8.4 μl O2×10−4 per hour.
    Type of Medium: Electronic Resource
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