ISSN:
1432-0533
Keywords:
Fluorescence Histochemistry
;
Sympathetic Denervation
;
Periarterial Nerve Stimulation
;
Regenerating Adrenergic Nerves
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary After sympathetic denervation of the guinea-pig distal colon the time course and the relationship between morphological and functional changes were studied, by using the fluorescence method and by evaluating the response of longitudinal muscle to periarterial nerve stimulation. The inhibitory response to sympathetic nerve stimulation was completely abolished 48 h after denervation. Tissue catecholamines can no longer be detected in either the intramural vessels or in the intramural plexuses 96 h after denervation, and in no preparation could they be observed again until 24 days after denervation. After 30 days catecholamines stores slowly began to reappear and were completely restored only 100–120 days after denervation. During the whole period of reinnervation the response to periarterial nerve stimulation was lacking. The inhibitory effect could be elicited only 130 days after denervation and before the morphological pattern had been completely restored.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00684522
