Electronic Resource
Springer
Acta neuropathologica
23 (1973), S. 326-333
ISSN:
1432-0533
Keywords:
Hexachlorophene Intoxication
;
Cerebral Edema
;
Status Spongiosus
;
Electron Microscopy
;
Myelinopathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Hexachlorophene intoxication produced cerebral edema in rats and mice characterized by the accumulation of fluid within myelin sheaths. Vessels remained impermeable to Trypan Blue. The amount of water in the brains of affected mice gradually returned to normal when the animals were put back on a normal diet. Correspondingly the status spongiosus decreased in severity in recovering animals. Some axonal degeneration occurred but there was no evidence of any breakdown of myelin lipids. The similarity of this encephalopathy to that seen following intoxication with triethyltin, isonicotinic acid hydrazide and cuprizone is emphasized. The potential toxicity of hexachlorophene to human infants is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687462
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