ISSN:
1432-0533
Keywords:
Alzheimer's disease
;
Dementia
;
Amyloid
;
Neurofibrillary tangles
;
Entorhinal region
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cases of old-aged demented individuals exhibited abundant cortical amyloid deposits but only small numbers of neurofibrillary changes. Neuritic plaques were rare or absent. Neither Ammon's horn nor isocortex revealed sufficiently large numbers of tangles to permit the diagnosis of fully developed Alzheimer's disease. Dense accumulations of neurofibrillary tangles and neuropil threads occurred only in layer Pre-α (II) of the entorhinal region. This pattern of cortical destruction may represent a variant of Alzheimer's disease or an initial stage of this disorder.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294607
