ISSN:
1432-0533
Keywords:
Key words Corticobasal degeneration
;
Tau
;
Gallyas
;
Autopsy
;
Cytoskeletal protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract An autopsy case of clinically diagnosed “corticobasal degeneration (CBD)” was investigated. In addition to status spongiosus and neuronal achormasia around the central sulcus, cortical pyramidal neurons and thread-like structures were densely stained by Gallyas stain and tau immunohistochemistry, but apparent fibrillary structures like Alzheimer's disease neurofibrillary tangle were absent. Bodian, methenamine-Bodian, Congo red, thioflavin S, or Bielshowsky stains failed to visualize these structures. They were not stained by immunohistochemical stain with anti-ubiquitin antibody. The widespread cytoskeletal pathology, which is distinct from that in Alzheimer's disease or progressive supranuclear palsy, is suggestive of CBD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310383