ISSN:
1432-0533
Keywords:
Human immunodeficiency virus neuronal loss
;
Dementia
;
Stereology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia. However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undertaken a stereological determination of the neuronal numerical density and neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were prospectively clinically characterized, with dementia identified or excluded, and antiretroviral medication documented. This study combines morphometric techniques with prospective clinical assessment of dementia. As previously demonstrated, all patients dying with AIDS showed neuronal loss, but this was not related to the presence of HIV-associated dementia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296490
